Key result
Atrial natriuretic factor infusion in pre-hypertensive men revealed decreased basal plasma c-GMP and blunted c-GMP response (p<0.05 to <0.01), despite normal renal excretory responses.
Why the study?
Does ANF infusion alter plasma c-GMP and renal responses differently in normotensive sons of hypertensive parents compared to sons of normotensive parents?
Population
14 subjects
Comparison
Atrial natriuretic factor infusions at 0.004… vs Vehicle infusion
Design
RCT, randomized sequence, single-blind
Follow-up
90 minutes per infusion
Authors
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Disturbed ANF-cGMP signaling appears early in pre-hypertension; extends mechanistic models beyond renal excretory responses.
RCT (n=14)
Single-blind
randomized sequence
Does ANF infusion alter plasma c-GMP and renal responses differently in normotensive sons of hypertensive parents compared to sons of normotensive parents?
p-value: p=<0.001
Pre-hypertensive individuals exhibit a disturbance in the ANF-c-GMP regulatory pathway at the circulatory level, with lower basal plasma c-GMP and blunted c-GMP response to ANF, despite normal renal responses.
Ferrari et al. (1996) conducted an RCT in Pre-hypertension (n=14). Atrial natriuretic factor (ANF) vs. Vehicle was evaluated on Plasma immunoreactive ANF and c-GMP, effective renal plasma flow, glomerular filtration rate, and urinary excretions (p=<0.001). Atrial natriuretic factor infusion in pre-hypertensive men revealed decreased basal plasma c-GMP and blunted c-GMP response (p<0.05 to <0.01), despite normal renal excretory responses.
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