Why the study?
Are vasodilator responses to atrial natriuretic peptide impaired in patients with essential hypertension compared to normotensive controls?
Population
Male patients with essential hypertension as the only cardiovascular risk factor and normotensive controls…
Comparison
Intra-arterial infusion of synthetic human ANP… vs Normotensive controls
Design
Case-control
Authors
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Impaired ANP vasodilation in essential hypertension may reflect receptor dysfunction; hypothesis-generating for ANP pathway studies but does not inform practice.
Are vasodilator responses to atrial natriuretic peptide impaired in patients with essential hypertension compared to normotensive controls?
Patients with essential hypertension exhibit impaired vascular vasodilator responses to atrial natriuretic peptide, suggesting receptor or postreceptor dysfunction in the ANP/GC-A pathway.
Bulut et al. (2003) studied this question.
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