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April 1, 1991AJP Renal Physiology

ANF-mediated renal cGMP generation in congestive heart failure

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Why the study?

Does ANF administration or endogenous ANF increase renal cGMP production and sodium excretion in dogs with pacing-induced CHF?

Population

Conscious dogs with congestive heart failure (CHF) produced by 6 days of rapid ventricular pacing (n=6)

Comparison

Exogenous ANF administration and endogenous ANF… vs Baseline (before CHF)

Design

Preclinical

Follow-up

6 days

Authors

KMK. B. MarguliesMayo ClinicDHD. M. HeubleinMayo ClinicMPMark A. PerrellaBrigham and Women's Hospital

Discussion

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Implication

May explain sodium retention via renal ANF resistance in advanced CHF; leaves open cGMP-targeted interventions in clinical trials.

Structured PICO

Does ANF administration or endogenous ANF increase renal cGMP production and sodium excretion in dogs with pacing-induced CHF?

P
Population
Conscious dogs with congestive heart failure (CHF) produced by 6 days of rapid ventricular pacing (n=6)
I
Intervention
Exogenous ANF administration (10 micrograms/kg iv) and endogenous ANF during the evolution of CHF
C
Comparator
Baseline (before CHF)
O
Outcome
Natriuretic and cGMP responses (sodium excretion and net renal generation of cGMP)surrogate

Renal ANF resistance and sodium retention in advanced congestive heart failure are linked to attenuated renal cGMP responses to ANF.

Cite This Study

Margulies et al. (1991) studied this question.

synapsesocial.com/papers/6a1ec4adbf2a5d44faaf4beahttps://doi.org/10.1152/ajprenal.1991.260.4.f562

Topics

HFrEF treatmentHeart failure
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glomerular atrial natriuretic factor receptors in experimental congestive heart failure1993 · 10 citations
  2. 2Possibility of downregulation of atrial natriuretic peptide receptor coupled to guanylate cyclase in peripheral vascular beds of patients with chronic severe heart failure.1993 · 167 citations
  3. 3Role of endogenous atrial natriuretic factor in acute congestive heart failure.1989 · 64 citations
  4. 4In vivo evidence that cGMP is the second messenger for atrial natriuretic factor.1986 · 87 citations
  5. 5Atrial natriuretic peptide and renal cGMP in rats with experimental heart failure1991 · 29 citations