October 1, 1991Canadian Journal of Physiology and Pharmacology
Pathophysiology of congestive heart failure: role of atrial natriuretic factor and therapeutic implications
Population
Congestive heart failure
Design
Review
Authors
Discussion
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Implication
May support NEP inhibition evaluation in HF; leaves open confirmation in randomized trials.
Structured PICO
P
Population
Congestive heart failure
I
Intervention
Agents that increase circulating atrial natriuretic factor (ANF) and/or enhance its local action (e.g., neutral endopeptidase 24.11 inhibitors, ANF clearance receptor blockers)
Agents that increase circulating atrial natriuretic factor or enhance its local action, such as neutral endopeptidase inhibitors, have potential therapeutic efficacy in congestive heart failure.
Cite This Study
Perrella et al. (1991) studied this question.