October 1, 1988American Journal of Hypertension
The Atrial Peptide System in Cardiac Disease
Population
Patients with congestive heart failure (CHF)
Design
Review
Authors
Discussion
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Implication
May limit ANF therapy in heart failure due to renal hyporesponsiveness; leaves open whether targeting intrarenal RAA or perfusion restores responsiveness.
Structured PICO
P
Population
Patients with congestive heart failure (CHF)
I
Intervention
Atrial natriuretic factor (ANF)
This review highlights the pathophysiological role of ANF in congestive heart failure, noting that despite elevated circulating levels, renal hyporesponsiveness limits its therapeutic efficacy.
Cite This Study
John C. Burnett (1988) studied this question.