Key result
ANF modulates volume control by increasing sodium excretion, antagonizing vasoconstriction, and shifting fluid interstitially.
Design
Review
Authors
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ANF's volume-modulating actions inform HF pathophysiology; confirms mechanisms but leaves open therapeutic targeting pending trials.
This review summarizes the physiological role of atrial natriuretic factor in volume control, sodium excretion, and pressure-volume homeostasis.
Thomas Maack (1996) reported a review. Atrial natriuretic factor (ANF) was evaluated. Atrial natriuretic factor (ANF) acts as a physiological modulator of volume control by increasing sodium excretion, antagonizing vasoconstriction, and shifting fluid to the interstitial compartment.
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