Population
Rats with moderate high-output heart failure induced by an aortocaval (AC) shunt
Comparison
Aortocaval (AC) shunt vs Sham-operated controls
Design
Preclinical
Authors
Loading...
ANF receptor downregulation appears tissue-specific in this rat HF model; leaves open relevance to human disease and therapy.
In a rat model of high-output heart failure, elevated plasma ANF levels are associated with divergent regulation of ANF receptors, showing downregulation in vascular membranes but no change in glomerular or papillary receptors.
García et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: