Why the study?
Does moderate volume expansion induce atrial natriuretic factor release and natriuresis in rats with high-output heart failure compared to sham-operated controls?
Population
Rats with high-output heart failure induced by aortocaval (AC) shunts
Comparison
Moderate volume expansion performed in conscious… vs Sham-operated control rats
Design
Preclinical
Authors
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Preserved ANF release and natriuresis after volume expansion in high-output HF rats; leaves open translation to human HF.
Does moderate volume expansion induce atrial natriuretic factor release and natriuresis in rats with high-output heart failure compared to sham-operated controls?
In a rat model of high-output heart failure, ANF release and natriuresis are conserved following moderate volume expansion despite elevated basal ANF levels.
García et al. (1990) studied this question.
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