Why the study?
Does an aortocaval fistula model of heart failure alter the glomerular response to atrial natriuretic peptide in rats?
Population
Male Sprague-Dawley rats with aortocaval fistula and control rats.
Comparison
Aortocaval fistula creation below the level of… vs Control rats without AC fistula.
Design
Preclinical
Follow-up
6 weeks
Authors
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Impaired ANP signaling in this rat HF model; leaves open its role in clinical sodium retention.
Does an aortocaval fistula model of heart failure alter the glomerular response to atrial natriuretic peptide in rats?
In a rat model of high-output heart failure, reduced glomerular generation of cGMP in response to ANP suggests a mechanism for the blunted natriuretic response and sodium retention seen in heart failure.
Norling et al. (1996) studied this question.
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