Why the study?
Does 1-K,1C hypertension alter the regulation of glomerular and papillary ANF receptor subtypes in rats?
Population
One-kidney, one clip (1-K,1C) hypertensive rats and normotensive uninephrectomized controls
Comparison
One-kidney, one clip (1-K,1C) hypertension model vs Normotensive uninephrectomized control rats
Design
Preclinical
Authors
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Suggests potential impact on renal sodium handling in hypertension; hypothesis-generating and leaves open human translation.
Does 1-K,1C hypertension alter the regulation of glomerular and papillary ANF receptor subtypes in rats?
In 1-K,1C hypertensive rats, glomerular ANF receptors are downregulated and papillary receptors are modestly augmented, suggesting altered renal sodium and water handling.
Bonhomme et al. (1993) studied this question.
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