July 1, 1988Journal of Hypertension

Atrial natriuretic factor: specific binding to renal glomeruli during the development of two-kidney, one clip hypertension in the rat

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Population

Rats (two-kidney, one clip [2-K, 1C] hypertension model)

Comparison

Two-kidney, one clip surgery to induce… vs Sham-operated normotensive controls

Design

Preclinical

Follow-up

Up to 7 weeks

Authors

GGG. GauquelinUniversité Claude Bernard Lyon 1 ESErnesto L. SchiffrinMontreal Clinical Research Institute MCMarc CantinBrigham and Women's Hospital

Discussion

Member takes

Implication

May implicate ANF receptor changes in renal sodium handling in renovascular hypertension; leaves open translation to human disease.

Structured PICO

Population

Rats (two-kidney, one clip [2-K, 1C] hypertension model)

Intervention

Two-kidney, one clip (2-K, 1C) surgery to induce hypertension

Comparator

Sham-operated normotensive controls

Outcome

Blood pressure, atrial and plasma concentrations of atrial natriuretic factor (ANF), hematocrit, and renal glomerular ANF receptorssurrogate

In a rat model of 2-K, 1C hypertension, plasma ANF is elevated and renal glomerular ANF receptor density changes dynamically, suggesting a role in differential sodium handling.

Cite This Study

Gauquelin et al. (1988) studied this question.

synapsesocial.com/papers/6a724949c1a24a6142dbd2fc https://doi.org/10.1097/00004872-198807000-00011

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