What question did this study set out to answer?

To examine alterations in blood pressure, atrial natriuretic factor levels, hematocrit, and renal glomerular ANF receptors in one-kidney, one-clip hypertensive rats before and after surgical unclipping.

February 1, 1988HypertensionOpen Access

Renal glomerular atrial natriuretic factor receptors in one-kidney, one clip rats.

View Full Paper

Ask AI

Bookmark

Why the study?

Does removal of the arterial clip affect blood pressure, ANF levels, and renal glomerular ANF receptors in 1K1C hypertensive rats?

Population

One-kidney, one clip (1K1C) hypertensive rats and normotensive uninephrectomized controls

Comparison

Removal of the arterial clip (unclipping) vs Before unclipping and normotensive…

Design

Preclinical

Follow-up

Up to 24 hours after unclipping

Authors

RGR. GarcíaUniversidad Complutense de Madrid GGG. GauquelinUniversité Claude Bernard Lyon 1 MCM. CantinHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

May implicate ANF receptors in post-unclipping natriuresis in rats; leaves open relevance to human hypertension.

Key Points

To examine alterations in blood pressure, atrial natriuretic factor levels, hematocrit, and renal glomerular ANF receptors in one-kidney, one-clip hypertensive rats before and after surgical unclipping.
Evaluated one-kidney, one-clip (1K1C) hypertensive rats alongside normotensive uninephrectomized control rats.
Measured blood pressure, hematocrit, plasma and atrial ANF concentrations, and glomerular ANF receptor density and affinity before, 6 hours after, and 24 hours after removal of the arterial clip.
Blood pressure normalized within 6 hours of clip removal, accompanied by a sharp decline in plasma ANF and resolution of hematocrit differences, indicating plasma volume contraction.
Glomerular ANF receptor population was significantly reduced in hypertensive 1K1C rats relative to controls, but exhibited a twofold increase in number and binding affinity 24 hours following unclipping.

Structured PICO

Does removal of the arterial clip affect blood pressure, ANF levels, and renal glomerular ANF receptors in 1K1C hypertensive rats?

Population

One-kidney, one clip (1K1C) hypertensive rats and normotensive uninephrectomized controls

Intervention

Removal of the arterial clip (unclipping)

Comparator

Before unclipping and normotensive uninephrectomized controls

Outcome

Blood pressure, atrial and plasma concentrations of atrial natriuretic factor (ANF), hematocrit, and renal glomerular ANF receptorssurrogate

Up-regulation and enhanced affinity of glomerular ANF receptors following unclipping may contribute to natriuresis in 1K1C hypertensive rats.

Cite This Study

García et al. (1988) studied this question.

synapsesocial.com/papers/6a85467eff13e6e4e743ddf1 https://doi.org/10.1161/01.hyp.11.2.185

View Full Paper

Ask AI

Bookmark

Renal glomerular atrial natriuretic factor receptors in one-kidney, one clip rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Renal glomerular atrial natriuretic factor receptors in one-kidney, one clip rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider