February 1, 1989AJP Regulatory Integrative and Comparative Physiology
Clearance function of type C receptors of atrial natriuretic factor in rats
Population
Anesthetized rats
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not inform ANF therapies in patients; leaves open whether C-ANF receptors regulate human ANF homeostasis.
Structured PICO
P
Population
Anesthetized rats
I
Intervention
C-ANF-(4-23) [des[Gln18Ser19Gly20Leu21Gly22]rANF-(3-23)-NH2] at 1 and 10 micrograms.min-1.kg body wt-1
O
Outcome
Pharmacokinetics and hydrolysis of 125I-labeled ANF-(1-28) (initial plasma concentration, volume of distribution at steady state [Vss], metabolic clearance rate [MCR], and appearance of hydrolytic products)surrogate
C-ANF receptors are mainly responsible for the large volume of distribution and fast metabolic clearance rate of ANF in rats, playing an important role in circulating ANF homeostasis.
Cite This Study
Almeida et al. (1989) studied this question.