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January 1, 1991AJP Regulatory Integrative and Comparative Physiology

Influence of C-ANF receptor and neutral endopeptidase on pharmacokinetics of ANF in rats

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Authors

PCPeter ChiuBoston Children's Hospital GTGlen TetzloffMerck & Co., Inc., Rahway, NJ, USA (United States)MRMaurizio RomanoOspedale degli Infermi

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Implication

C-ANF receptor blockade markedly extends ANF exposure in rats; leaves open whether this pathway dominates human natriuretic peptide kinetics.

Key Points

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Cite This Study

Chiu et al. (1991) studied this question.

synapsesocial.com/papers/6a84f89d5d33534bf2de0652 https://doi.org/10.1152/ajpregu.1991.260.1.r208

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Clearance receptor and neutral endopeptidase-mediated metabolism of atrial natriuretic factor1992 · 38 citations
2Clearance function of type C receptors of atrial natriuretic factor in rats1989 · 134 citations
3Basal and volume expansion-stimulated plasma atrial natriuretic peptide concentrations and hemodynamics in conscious rats: effects of SCH 39.370, an endopeptidase inhibitor, and C-ANF-(4-23), a clearance receptor ligand.1992 · 22 citations
4Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure1997 · 51 citations
5Interaction of a Neutral Endopeptidase Inhibitor with an ANP-C Receptor Ligand in Anesthetized Dogs1995 · 10 citations