Key result
Coadministration of (S)-thiorphan and AP 811 increased urinary excretion of volume, sodium, cGMP, and ANP compared with vehicle controls in anesthetized dogs.
Why the study?
Does coadministration of a neutral endopeptidase inhibitor and an ANP-C receptor ligand improve endocrine and renal parameters in anesthetized dogs?
Does coadministration of a neutral endopeptidase inhibitor and an ANP-C receptor ligand improve endocrine and renal parameters in anesthetized dogs?
Dual blockade of ANP degradation pathways with a neutral endopeptidase inhibitor and an ANP-C receptor ligand synergistically enhances natriuretic peptide levels and diuresis in an animal model.
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Enhances natriuresis via dual ANP blockade in dogs; hypothesis-generating, leaves open human translation.
Wegner et al. (1995) studied this question. Coadministration of (S)-thiorphan and AP 811 vs. Vehicle controls and either substance alone was evaluated on Endocrine and renal parameters (urinary excretion of volume and sodium, cGMP and ANP, plasma cGMP, plasma ANP, plasma renin activity). Coadministration of (S)-thiorphan and AP 811 increased urinary excretion of volume, sodium, cGMP, and ANP compared with vehicle controls in anesthetized dogs.
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