Population
Anesthetized rats (six separate groups) and conscious spontaneously hypertensive rats (SHR)
Comparison
Phosphoramidon or thiorphan at low, medium, or… vs ANP alone (without thiorphan or phosphoramidon)
Design
Preclinical
Authors
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NEP inhibition may enhance ANP effects in hypertensive rat models; leaves open clinical translation and requires human trials.
Enzymatic breakdown by NEP 24.11 plays an important role in regulating the actions of ANP, as its inhibition potentiates and prolongs ANP's pharmacologic effects in vivo.
Webb et al. (1989) studied this question.
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