August 1, 1989Journal of Cardiovascular Pharmacology

Potentiation of the Depressor Responses to Atrial Natriuretic Peptides in Conscious SHR by an Inhibitor of Neutral Endopeptidase

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Why the study?

Does the NEP inhibitor SQ 29,072 improve the depressor response to ANP in conscious spontaneously hypertensive rats?

Population

Conscious spontaneously hypertensive rats (SHR)

Comparison

Neutral endopeptidase inhibitor SQ 29,072… vs Vehicle treatment prior to ANP

Design

Preclinical

Follow-up

Up to 60 minutes

Authors

ASAndrea A. SeymourMerck & Co., Inc., Rahway, NJ, USA (United States)JSJoel N. SwerdelJohnson & Johnson (United States)SFSusan A. FennellBristol-Myers Squibb (Germany)

Discussion

Member takes

Implication

NEP inhibition potentiates ANP effects in hypertensive rats; leaves open translation to human therapy.

Structured PICO

Does the NEP inhibitor SQ 29,072 improve the depressor response to ANP in conscious spontaneously hypertensive rats?

Population

Conscious spontaneously hypertensive rats (SHR)

Intervention

Neutral endopeptidase (NEP) inhibitor SQ 29,072 (3, 10, 30, and 100 mumol/kg i.v.) administered prior to atrial natriuretic peptides (ANP)

Comparator

Vehicle treatment prior to ANP

Outcome

Area over the curve (AOC) of the depressor response to ANPsurrogate

The NEP inhibitor SQ 29,072 significantly potentiates the depressor response to ANP in conscious spontaneously hypertensive rats, suggesting that NEP inactivates ANP in vivo.

Cite This Study

Seymour et al. (1989) studied this question.

synapsesocial.com/papers/6a74756bd93df8ecca090d8b https://doi.org/10.1097/00005344-198908000-00003

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Potentiation of the Depressor Responses to Atrial Natriuretic Peptides in Conscious SHR by an Inhibitor of Neutral Endopeptidase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Potentiation of the Depressor Responses to Atrial Natriuretic Peptides in Conscious SHR by an Inhibitor of Neutral Endopeptidase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider