Population
Conscious, unrestrained spontaneously hypertensive rats
Comparison
SQ 29,072 at doses of 3, 10, 30, or 100 μmol/kg… vs Vehicle combined with atrial natriuretic factor-
Design
Preclinical
Follow-up
up to 2 hours
Authors
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NEP inhibition augments ANF natriuresis in hypertensive rats; leaves open clinical translation.
Neutral endopeptidase inhibition with SQ 29,072 enhances and prolongs the depressor, natriuretic, and cyclic GMP responses to exogenous atrial natriuretic factor in spontaneously hypertensive rats.
Seymour et al. (1989) studied this question.
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