May 1, 1992British Journal of PharmacologyOpen Access

Effects of the neutral endopeptidase inhibitor, SQ 28,603, on regional haemodynamic responses to atrial natriuretic peptide or proendothelin‐1 1–38 in conscious rats

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Population

Conscious Long Evans rats

Comparison

SQ 28,603, a neutral endopeptidase inhibitor vs Baseline (before administration of SQ 28,603)

Design

Preclinical

Follow-up

20 min

Authors

SGSheila M. GardinerUniversity of Nottingham PKP.A. KempAnalytical Engineering (United States)TBT. BennettUniversity of Manchester

Discussion

Member takes

Implication

Does not yet inform clinical practice; leaves open translation of dual NEP/ECE inhibition from animal models.

Structured PICO

Population

Conscious Long Evans rats

Intervention

SQ 28,603 (50 mg kg-1, i.v.), a neutral endopeptidase (NEP) inhibitor

Comparator

Baseline (before administration of SQ 28,603)

Outcome

Regional haemodynamic responses to atrial natriuretic peptide (ANP) or proendothelin-1 [1-38]surrogate

The NEP inhibitor SQ 28,603 prolongs the effects of ANP and attenuates the effects of proendothelin-1, suggesting it inhibits both ANP degradation and proendothelin-1 conversion to endothelin-1.

Cite This Study

Gardiner et al. (1992) studied this question.

synapsesocial.com/papers/6a838761637346ad436fffc0 https://doi.org/10.1111/j.1476-5381.1992.tb14312.x

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Effects of the neutral endopeptidase inhibitor, SQ 28,603, on regional haemodynamic responses to atrial natriuretic peptide or proendothelin‐1 1–38 in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of the neutral endopeptidase inhibitor, SQ 28,603, on regional haemodynamic responses to atrial natriuretic peptide or proendothelin‐1 1–38 in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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