Thiorphan, an Inhibitor of Endopeptidase 24.11, Potentiates the Natriuretic Activity of Atrial Natriuretic Peptide

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Why the study?

Does thiorphan potentiate the natriuretic activity of atrial natriuretic peptide in anesthetized rats?

Population

Anesthetized rats

Design

Preclinical

Authors

Discussion

Hypothesis-generating for NEP inhibition to augment ANP natriuresis; leaves open human translation and clinical utility.

Does thiorphan potentiate the natriuretic activity of atrial natriuretic peptide in anesthetized rats?

Population

Anesthetized rats

Intervention

Thiorphan (endopeptidase 24.11 inhibitor) alone and during infusion of ANP(99-126) (330 ng/kg/min i.v.)

Outcome

Plasma ANP concentrations, urine flow, urinary sodium excretion, and arterial pressuresurrogate

Inhibition of endopeptidase 24.11 by thiorphan potentiates the renal actions of atrial natriuretic peptide by inhibiting its degradation in vivo.

Trapani et al. (1989) studied this question.

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