Key result
Thiorphan induced natriuresis in cirrhotic rats by a direct renal medullary mechanism via cGMP and Na+ - K+ ATPase, without affecting systemic hemodynamics.
Why the study?
Does thiorphan improve cardiovascular and renal function in a rat cirrhosis model?
Does thiorphan improve cardiovascular and renal function in a rat cirrhosis model?
Thiorphan induces natriuresis in cirrhotic rats via a direct renal medullary mechanism without affecting systemic hemodynamics, highlighting a potential therapeutic avenue for ascites.
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Should not alter cirrhosis management; leaves open thiorphan for ascites pending human trials.
Park et al. (2003) studied Cirrhosis. Thiorphan vs. Sham-operated controls was evaluated on Hemodynamic and renal effects (cardiac output, systemic vascular resistance, GFR, urine sodium excretion). Thiorphan induced natriuresis in cirrhotic rats by a direct renal medullary mechanism via cGMP and Na+ - K+ ATPase, without affecting systemic hemodynamics.
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