Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1993AJP Heart and Circulatory Physiology

Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does C-ANF-(4-23) infusion alter plasma ANF levels and clearance in anesthetized dogs with experimental congestive heart failure compared to normal controls?

Population

Anesthetized dogs, normal (control) and with experimental congestive heart failure (CHF)

Comparison

Infusion of an ANF ligand specific for ANFR-C… vs Normal dogs vs. CHF dogs, and baseline vs…

Design

Preclinical

Authors

MPMA PerrellaHarvard University PressLAL L AarhusMayo ClinicDHD. M. HeubleinMayo Clinic

Discussion

Loading...

Member takes

Implication

Altered ANF clearance in experimental CHF cautions against clinical translation; extends evidence of ANFR-C downregulation but remains hypothesis-generating.

Structured PICO

Does C-ANF-(4-23) infusion alter plasma ANF levels and clearance in anesthetized dogs with experimental congestive heart failure compared to normal controls?

P
Population
Anesthetized dogs, normal (control) and with experimental congestive heart failure (CHF)
I
Intervention
Infusion of an ANF ligand specific for ANFR-C [C-ANF-(4-23)]
C
Comparator
Normal (control) dogs vs. CHF dogs, and baseline vs. post-infusion
O
Outcome
Plasma ANF levels and regional pulmonary and renal ANF clearancessurrogate

ANFR-C plays a significant role in ANF metabolism and clearance, but its pulmonary clearance function appears altered or downregulated in experimental congestive heart failure with chronically elevated ANF.

Cite This Study

Perrella et al. (1993) studied this question.

synapsesocial.com/papers/6a1ca87f5a7763abe7899224https://doi.org/10.1152/ajpheart.1993.265.1.h401

Topics

Heart failureHFrEF treatment
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clearance receptor-mediated control of atrial natriuretic factor in experimental congestive heart failure1994 · 17 citations
  2. 2Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs.1991 · 29 citations
  3. 3Clearance function of type C receptors of atrial natriuretic factor in rats1989 · 134 citations
  4. 4Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.1986 · 712 citations
  5. 5Atrial Natriuretic Factor: Its Possible Role in Hypertension and Congestive Heart Failure1989 · 12 citations