What question did this study set out to answer?

To establish exoRBase, a centralized web repository that catalogs, characterizes, and visualizes circular RNA, long non-coding RNA, and messenger RNA profiles derived from human blood exosomes in health and disease.

September 24, 2017Nucleic Acids ResearchOpen Access

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

View Full Paper

Ask AI

Bookmark

Authors

SLShengli LiShanghai Jiao Tong University YLYuchen LiPeking University BCBing ChenChongqing Jiaotong University

Discussion

Member takes

Implication

Database analysis reveals extensive circular, noncoding, and messenger RNA profiles in human blood exosomes, highlighting new avenues for noninvasive disease biomarker discovery.

Key Points

To establish exoRBase, a centralized web repository that catalogs, characterizes, and visualizes circular RNA, long non-coding RNA, and messenger RNA profiles derived from human blood exosomes in health and disease.
Curated and normalized RNA-seq data from human blood exosomes obtained from healthy individuals and patients with various diseases.
Integrated published experimental validation data along with annotations of transcript expression levels and predicted tissues of origin.
Cataloged 58,330 circular RNAs, 15,501 long non-coding RNAs, and 18,333 messenger RNAs in the initial database release.
Implemented dynamic web-based expression visualization across distinct disease conditions to facilitate comparative exosomal biomarker discovery.

Cite This Study

Li et al. (2017) studied this question.

synapsesocial.com/papers/69d8520452654bb436d1915d https://doi.org/10.1093/nar/gkx891

View Full Paper

Ask AI

Bookmark

September 24, 2017Nucleic Acids ResearchOpen Access

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

View Full Paper

Ask AI

Bookmark

Authors

SLShengli LiShanghai Jiao Tong University YLYuchen LiPeking University BCBing ChenChongqing Jiaotong University

Discussion

Member takes

Implication

Database analysis reveals extensive circular, noncoding, and messenger RNA profiles in human blood exosomes, highlighting new avenues for noninvasive disease biomarker discovery.

Key Points

To establish exoRBase, a centralized web repository that catalogs, characterizes, and visualizes circular RNA, long non-coding RNA, and messenger RNA profiles derived from human blood exosomes in health and disease.
Curated and normalized RNA-seq data from human blood exosomes obtained from healthy individuals and patients with various diseases.
Integrated published experimental validation data along with annotations of transcript expression levels and predicted tissues of origin.
Cataloged 58,330 circular RNAs, 15,501 long non-coding RNAs, and 18,333 messenger RNAs in the initial database release.
Implemented dynamic web-based expression visualization across distinct disease conditions to facilitate comparative exosomal biomarker discovery.

Cite This Study

Li et al. (2017) studied this question.

synapsesocial.com/papers/69d8520452654bb436d1915d https://doi.org/10.1093/nar/gkx891

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark