What question did this study set out to answer?

To evaluate whether body composition, specifically lean body mass, independently predicts toxicity from 5-fluorouracil chemotherapy dosed according to conventional body surface area.

June 1, 2007Clinical Cancer Research

Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity

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Authors

CPCarla M. PradoUniversity of Alberta VBVickie E. BaracosPennington Biomedical Research Center LMLinda J. McCargarUniversity of New Brunswick

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Implication

Clinical study demonstrates that low lean body mass predicts 5-fluorouracil toxicity in females, suggesting sex differences in body composition alter drug tolerance.

Key Points

To evaluate whether body composition, specifically lean body mass, independently predicts toxicity from 5-fluorouracil chemotherapy dosed according to conventional body surface area.
Assessed cancer patients receiving 5-fluorouracil (5-FU) chemotherapy dosed per unit of body surface area (BSA).
Analyzed the relationship between lean body mass (LBM) measurements and toxicity outcomes, stratified by sex.
Low lean body mass significantly predicted chemotherapy toxicity in female patients receiving standard BSA-dosed 5-FU.
Differences in body composition between females and males qualitatively explained observed sex-based disparities in chemotherapy-related toxicity.

Cite This Study

Prado et al. (2007) studied this question.

synapsesocial.com/papers/69d8565fd56ca42147d186a5 https://doi.org/10.1158/1078-0432.ccr-06-3067

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Implication

Clinical study demonstrates that low lean body mass predicts 5-fluorouracil toxicity in females, suggesting sex differences in body composition alter drug tolerance.

Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity

Discussion

Member takes

Implication

Key Points

Cite This Study

Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity

Discussion

Member takes

Implication

Key Points

Cite This Study

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