Key result
Fluorouracil pharmacokinetics were better predicted by fat-free mass and total body water than standard parameters, with FFM-normalized clearance being significantly higher in women than men (P=0.003).
Why the study?
Do body composition parameters better predict fluorouracil pharmacokinetics than standard anthropometric parameters in patients with colorectal cancer?
Observational (n=34)
Do body composition parameters better predict fluorouracil pharmacokinetics than standard anthropometric parameters in patients with colorectal cancer?
Mean Difference: 0.008 (95% CI 0.003–0.012)
Absolute Event Rate: 0.03% vs 0.022%
p-value: p=0.003
Fluorouracil pharmacokinetics are better predicted by fat-free mass, total body water, and sex than by standard anthropometric parameters, suggesting bioelectrical impedance analysis could improve dosing.
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Body composition parameters merit evaluation for fluorouracil dosing models; hypothesis-generating without outcome data to guide practice.
Gusella et al. (2002) conducted an observational in Colorectal cancer (n=34). Female sex vs. Male sex was evaluated on Fat free mass (FFM)-normalized fluorouracil clearance (l min(-1) kg(-1)) (MD 0.008, 95% CI 0.003-0.012, p=0.003). Fluorouracil pharmacokinetics were better predicted by fat-free mass and total body water than standard parameters, with FFM-normalized clearance being significantly higher in women than men (P=0.003).
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