Should insulin resistance (HOMA-IR), insulin secretion (HOMA-β), and visceral fat area be considered for improving the performance of diabetes risk prediction models

Huanhuan Hu; Tohru Nakagawa; Toru Honda; Shuichiro Yamamoto; Tetsuya Mizoue

doi:10.1136/bmjdrc-2023-003680

January 1, 2024SHILAP Revista de lepidopterologíaOpen Access

Should insulin resistance (HOMA-IR), insulin secretion (HOMA-β), and visceral fat area be considered for improving the performance of diabetes risk prediction models

View Full Paper

Ask AI

Bookmark

Share

Key Points

To determine whether adding measures of insulin resistance (HOMA-IR), insulin secretion (HOMA-β), or visceral fat area (VFA) improves the accuracy of standard diabetes risk prediction models.
Conducted a cohort study primarily composed of male workers.
Evaluated a baseline risk prediction model containing body mass index (BMI), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c).
Assessed model performance after incorporating HOMA-IR, HOMA-β, or substituting BMI with VFA.
The baseline prediction model incorporating BMI, FPG, and HbA1c effectively identified individuals at high risk for diabetes.
Adding HOMA-IR or HOMA-β, or substituting BMI with VFA, did not significantly improve model performance.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Cohort study reveals that adding insulin indices or visceral fat area does not improve diabetes risk prediction in male workers, suggesting standard metrics remain sufficient.

Abstract

This cohort study, primarily composed of male workers, suggests that a model with BMI, FPG, and HbA1c effectively identifies those at high diabetes risk. However, adding HOMA-IR, HOMA-β, or replacing BMI with VFA does not significantly improve the model. Further studies are needed to confirm our findings.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Hu et al. (2024) studied this question.

synapsesocial.com/papers/69d860a2e9c100a435ae29a8 https://doi.org/10.1136/bmjdrc-2023-003680

View Full Paper

Ask AI

Bookmark

Share

Should insulin resistance (HOMA-IR), insulin secretion (HOMA-β), and visceral fat area be considered for improving the performance of diabetes risk prediction models

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Should insulin resistance (HOMA-IR), insulin secretion (HOMA-β), and visceral fat area be considered for improving the performance of diabetes risk prediction models

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading