What question did this study set out to answer?

To determine whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) independently predicts cardiovascular disease in patients with type 2 diabetes.

July 1, 2002Diabetes CareOpen Access

HOMA-Estimated Insulin Resistance Is an Independent Predictor of Cardiovascular Disease in Type 2 Diabetic Subjects

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Why the study?

Does HOMA-estimated insulin resistance predict cardiovascular disease in patients with type 2 diabetes?

Population

1,326 patients with type 2 diabetes examined within the Verona Diabetes Complications Study

Design

Cohort

Follow-up

mean 4.5 years

Authors

EBEnzo BonoraAzienda Ospedaliera Universitaria Integrata Verona GFG. FormentiniUniversity of Verona FCFrancesco CalcaterraUniversity of Verona

Discussion

Member takes

Implication

HOMA-IR may aid CVD risk stratification in type 2 diabetes; leaves open whether improving insulin sensitivity reduces events.

Key Points

To determine whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) independently predicts cardiovascular disease in patients with type 2 diabetes.
Evaluated baseline conventional cardiovascular risk factors and HOMA-IR in 1,326 patients with type 2 diabetes within the Verona Diabetes Complications Study.
Tracked cardiovascular disease (CVD) at baseline and after a mean follow-up of 4.5 years via clinical exams, electrocardiography, echo-Doppler of carotid and lower limb arteries, and medical records.
Identified 441 prevalent CVD cases at baseline and 126 incident CVD cases over the 4.5-year follow-up period.
Showed via multiple logistic regression that each 1-unit increase in (log)HOMA-IR independently predicted prevalent CVD at baseline (OR 1.31, 95% CI 1.10–1.56, P = 0.002) and incident CVD during follow-up (OR 1.56, 95% CI 1.14–2.12, P < 0.001).

Structured PICO

Does HOMA-estimated insulin resistance predict cardiovascular disease in patients with type 2 diabetes?

Population

1,326 patients with type 2 diabetes examined within the Verona Diabetes Complications Study

Intervention

HOMA-estimated insulin resistance (HOMA-IR)

Outcome

Aggregate end point including both fatal and nonfatal coronary, cerebrovascular, and peripheral vascular disease as well as ischemic electrocardiographic abnormalities and vascular lesions identified by echo-Dopplercomposite

HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in patients with type 2 diabetes, suggesting potential cardiovascular benefits of improving insulin sensitivity.

Cite This Study

Bonora et al. (2002) studied this question.

synapsesocial.com/papers/6a70f157ac440176ef29a04b https://doi.org/10.2337/diacare.25.7.1135

Topics

Women and heart disease Hypertension management

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HOMA-Estimated Insulin Resistance Is an Independent Predictor of Cardiovascular Disease in Type 2 Diabetic Subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

HOMA-Estimated Insulin Resistance Is an Independent Predictor of Cardiovascular Disease in Type 2 Diabetic Subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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