Key result
Higher insulin resistance (HOMA-IR) was significantly correlated with increased cardiovascular risk (Framingham Risk Score ≥20%), particularly in patients with type 2 diabetes (r=0.625).
Why the study?
Insulin resistance is interconnected with obesity and dyslipidemia as CVD risk factors, but its specific association with cardiovascular risk warranted further investigation.
Is insulin resistance quantified by HOMA-IR associated with increased cardiovascular risk in patients with type 2 diabetes compared to those without diabetes?
Cross-Sectional (n=400)
No
Is insulin resistance quantified by HOMA-IR associated with increased cardiovascular risk in patients with type 2 diabetes compared to those without diabetes?
Effect estimate: Spearman correlation coefficient 0.625 in T2DM group
p-value: p=0.001
Insulin resistance, quantified by HOMA-IR, is strongly correlated with elevated Framingham risk scores, especially in patients with type 2 diabetes.
No takes yet. Share an insight, caveat, or question.
May support HOMA-IR for CV risk stratification in T2D; hypothesis-generating, needs prospective validation.
Vladu et al. (2021) conducted a cross-sectional in Type 2 Diabetes Mellitus and Cardiovascular Risk (n=400). Insulin resistance (HOMA-IR) vs. Lower HOMA-IR / Absence of insulin resistance was evaluated on Correlation between HOMA-IR and Framingham Risk Score (FRS) (Spearman correlation coefficient 0.625 in T2DM group, p=0.001). Higher insulin resistance (HOMA-IR) was significantly correlated with increased cardiovascular risk (Framingham Risk Score ≥20%), particularly in patients with type 2 diabetes (r=0.625).
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