Why the study?
While insulin resistance predicts coronary artery disease in type 2 diabetes mellitus, how it impacts the severity of coronary atherosclerosis in non-diabetic patients is unknown.
Does insulin resistance (measured by HOMA-IR) predict the severity and extent of coronary atherosclerosis in non-diabetic patients?
Does insulin resistance (measured by HOMA-IR) predict the severity and extent of coronary atherosclerosis in non-diabetic patients?
In non-diabetic patients, insulin resistance measured by HOMA-IR is an independent predictor of severe and extensive coronary artery disease, suggesting its utility for risk stratification.
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May support HOMA-IR for risk stratification in non-diabetics; leaves open prospective validation before clinical adoption.
Strisciuglio et al. (2020) studied this question.
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