Key result
Insulin resistance shows no correlation with angiographic CAD severity in non-diabetic patients.
Why the study?
There are limited studies on the correlation between insulin resistance and severity of coronary artery disease in non-diabetic individuals.
Cross-Sectional (n=79)
No
Effect estimate: r=-0.053
p-value: p=0.64
Insulin resistance, as measured by HOMA-IR, does not significantly correlate with the angiographic severity of coronary artery disease in non-diabetic patients.
HOMA-IR does not support CAD severity assessment in non-diabetics; leaves open insulin resistance's role in non-diabetic atherosclerosis.
Objective: There is an increased risk of CAD in both diabetes and non-diabetes. Insulin resistance has been associated with development of CAD in this both populations. However, there are not many studies on correlation between insulin resistance and severity of CAD in non-diabetes. The present study aimed to establish a correlation between insulin resistance and severity of CAD in non-diabetic individuals.Methods: A cross-sectional study of 79 consecutive Non-diabetic patients undergoing coronary angiogram for evaluation of clinically suspected coronary artery disease at a tertiary care hospital in Mangalore, Karnataka were recruited. Clinical history, anthropometric and biochemical parameters were analyzed. Insulin resistance was determined by Homeostasis model assessment (HOMA-IR). The severity of CAD was assessed by modified Gensini score. Pearson correlation was done to find out the relation between HOMA-IR and Gensini core.Results: The correlation between log of HOMA-IR and severity of coronary artery disease as assessed by Gensini score (r = -0.053 and p= 0.64) was not significant in non-diabetic patients. The correlations between severity of coronary artery disease and other known risk factors of coronary artery disease were also was not significant.Conclusion: HOMA-IR is negatively associated with severity of CAD in non-diabetes.
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M Srinivasan (2016) conducted a cross-sectional in Coronary Artery Disease (n=79). Insulin resistance (HOMA-IR) was evaluated on Correlation between log of HOMA-IR and severity of CAD as assessed by Gensini score (r=-0.053, p=0.64). Insulin resistance, as measured by HOMA-IR, was not significantly correlated with the angiographic severity of coronary artery disease in non-diabetic patients (r=-0.053, p=0.64).
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