September 1, 1979American Journal of Epidemiology
An Investigation of Coronary Heart Disease in Families
Population
5209 adult men and women in the Framingham Heart Study cohort, and their children in the Framingham…
Design
Cohort
Follow-up
Continuous surveillance since 1948
Authors
Discussion
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Implication
Supports FOS representativeness for familial CVD research; extends generalizability of clustering analyses while leaving broader inferences open.
Key Points
- This research aims to understand the familial patterns and risk factors associated with coronary heart disease.
- Analyzed data from the Framingham Heart Study and the Framingham Offspring Study.
- Conducted biennial physical examinations on 5209 subjects since 1948.
- Examined families of the original FHS participants that began in 1971.
- No significant difference in coronary heart disease experiences among parents of participants and non-participants.
- Confirmed familial clustering of risk factors for coronary heart disease.
- Families included in the study reflect typical size and structure for their generation.
Structured PICO
P
Population
5209 adult men and women in the Framingham Heart Study (FHS) cohort, and their children in the Framingham Offspring Study (FOS)
O
Outcome
Coronary heart disease (CHD) experience and CHD risk factors
The Framingham Offspring Study provides a representative sample for investigating familial clustering of cardiovascular disease and its risk factors.
Cite This Study
Kannel et al. (1979) studied this question.