May 1, 1973Archives of Neurology

Pathogenesis of Demyelination Induced by a Mouse Hepatitis

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Population

Mice

Design

Preclinical

Authors

LWLeslie P. WeinerRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Should not yet inform human demyelinating disease management; hypothesis-generating for direct viral glial mechanisms.

Structured PICO

Population

Mice

Intervention

Inoculation of JHM virus (a neurotropic strain of mouse hepatitis virus)

Outcome

Production of demyelinative lesions and mechanism of demyelinationsurrogate

Demyelination induced by the JHM virus in mice is directly caused by viral infection of white matter glial cells rather than an immune-mediated mechanism.

Cite This Study

Leslie P. Weiner (1973) studied this question.

synapsesocial.com/papers/69d861e5e9c100a435ae2ab4 https://doi.org/10.1001/archneur.1973.00490230034003

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Ask AI

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Pathogenesis of Demyelination Induced by a Mouse Hepatitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathogenesis of Demyelination Induced by a Mouse Hepatitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider