Genetic Etiology for Alcohol-Induced Cardiac Toxicity
Why the study?
Does the presence of TTNtv worsen left ventricular ejection fraction in DCM patients who consume alcohol above recommended levels?
Population
Patients with alcoholic cardiomyopathy and dilated cardiomyopathy who consume alcohol above recommended levels
Design
Review
Authors
Discussion
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Implication
TTNtv-alcohol interaction in DCM is hypothesis-generating; should not yet change genetic testing or management recommendations.
Structured PICO
Does the presence of TTNtv worsen left ventricular ejection fraction in DCM patients who consume alcohol above recommended levels?
P
Population
Patients with alcoholic cardiomyopathy (ACM) and dilated cardiomyopathy (DCM) who consume alcohol above recommended levels
I
Intervention
Familial evaluation and genetic testing (specifically for TTNtv)
O
Outcome
Left ventricular ejection fraction (LVEF)surrogate
Familial evaluation and genetic testing should be considered in patients presenting with alcoholic cardiomyopathy due to the prevalent genetic predisposition of TTNtv.
Cite This Study
Ware et al. (2018) studied this question.