What question did this study set out to answer?

Establish unified, comprehensive clinical diagnostic criteria for IgG4-related disease across various involved organs for practical use by general physicians and nonspecialists.

February 1, 2012Modern Rheumatology

Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011

View Full Paper

Ask AI

Bookmark

Authors

HUHisanori UmeharaNagahama City Hospital KOKazuichi OkazakiKansai Medical University YMYasufumi MasakiKanazawa University

Discussion

Member takes

Overview

Consensus study defines diagnostic criteria for IgG4-related disease, indicating high sensitivity across multiple organ manifestations when paired with organ-specific guidelines.

Key Points

Establish unified, comprehensive clinical diagnostic criteria for IgG4-related disease across various involved organs for practical use by general physicians and nonspecialists.
Conducted a nationwide multidisciplinary collaboration in Japan involving two study groups (Umehara team, n=66; Okazaki team, n=56) covering rheumatology, gastroenterology, nephrology, pathology, and related fields.
Analyzed clinical symptoms, laboratory parameters, and biopsy specimens from patients presenting with multiorgan involvement to establish standardized diagnostic thresholds.
Consensus established two core criteria: serum IgG4 concentration >135 mg/dl, and biopsy findings showing >40% IgG4+/IgG+ plasma cell ratio alongside >10 IgG4+ cells per high-power field.
The comprehensive criteria provided adequate diagnostic sensitivity for Mikulicz's disease and kidney disease, but insufficient standalone sensitivity for type 1 autoimmune pancreatitis.
Combining comprehensive criteria with organ-specific guidelines increased diagnostic sensitivity to 100% for Mikulicz's disease, kidney disease, and autoimmune pancreatitis.

Cite This Study

Umehara et al. (2012) studied this question.

synapsesocial.com/papers/69d88ee2d2f7327e70ae36d2 https://doi.org/10.3109/s10165-011-0571-z

View Full Paper

Ask AI

Bookmark

February 1, 2012Modern Rheumatology

Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011

View Full Paper

Ask AI

Bookmark

Authors

HUHisanori UmeharaNagahama City Hospital KOKazuichi OkazakiKansai Medical University YMYasufumi MasakiKanazawa University

Discussion

Member takes

Overview

Consensus study defines diagnostic criteria for IgG4-related disease, indicating high sensitivity across multiple organ manifestations when paired with organ-specific guidelines.

Key Points

Establish unified, comprehensive clinical diagnostic criteria for IgG4-related disease across various involved organs for practical use by general physicians and nonspecialists.
Conducted a nationwide multidisciplinary collaboration in Japan involving two study groups (Umehara team, n=66; Okazaki team, n=56) covering rheumatology, gastroenterology, nephrology, pathology, and related fields.
Analyzed clinical symptoms, laboratory parameters, and biopsy specimens from patients presenting with multiorgan involvement to establish standardized diagnostic thresholds.
Consensus established two core criteria: serum IgG4 concentration >135 mg/dl, and biopsy findings showing >40% IgG4+/IgG+ plasma cell ratio alongside >10 IgG4+ cells per high-power field.
The comprehensive criteria provided adequate diagnostic sensitivity for Mikulicz's disease and kidney disease, but insufficient standalone sensitivity for type 1 autoimmune pancreatitis.
Combining comprehensive criteria with organ-specific guidelines increased diagnostic sensitivity to 100% for Mikulicz's disease, kidney disease, and autoimmune pancreatitis.

Cite This Study

Umehara et al. (2012) studied this question.

synapsesocial.com/papers/69d88ee2d2f7327e70ae36d2 https://doi.org/10.3109/s10165-011-0571-z

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark