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This investigation aims to understand the role of HLA-G in hematologic diseases characterized by impaired erythropoiesis.

April 10, 2026Human ImmunologyOpen Access

Bone marrow and peripheral blood HLA-G in hematologic diseases presenting with impaired erythropoiesis

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Investigation reveals HLA-G's impact on erythropoiesis in hematologic diseases, suggesting its therapeutic potential.

This investigation aims to understand the role of HLA-G in hematologic diseases characterized by impaired erythropoiesis.
Analyzed bone marrow and peripheral blood samples from 61 patients with various hematologic disorders.
Measured levels of soluble and membrane-bound HLA-G using ELISA and flow cytometry.
Utilized logistic regression to assess the relationship between sHLA-G levels and erythropoiesis impairment.
Bone marrow sHLA-G levels were significantly lower in patients compared to healthy individuals (p < 0.001).
A positive correlation between bone marrow and peripheral blood sHLA-G levels was observed (p < 0.05).
Increased HLA-G expression in myeloid precursors was noted after rEPO treatment in MDS patients.

Carvalho et al. (2026) studied this question.

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