What question did this study set out to answer?

The aim is to investigate high mannose glycans (HMGs) as markers for the lifespan and removal of red blood cells, particularly in relation to spleen function.

March 26, 2026American Journal of Hematology

High Mannose Glycans: A Marker of Early Red Cell Life and Death

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Authors

AKAzalea A. Khan DRDavid C. ReesKing's College Hospital BCBarnaby ClarkKing's College Hospital

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Implication

This research uncovers the role of high mannose glycans as markers for erythrocyte age in various disease states, indicating spleen function.

Key Points

The aim is to investigate high mannose glycans (HMGs) as markers for the lifespan and removal of red blood cells, particularly in relation to spleen function.
Measured high mannose glycans using flow cytometry in red cells from patients and controls.
Isolated reticulocytes and assessed their HMG levels compared to mature erythrocytes.
Evaluated correlations between HMG expression and clinical markers of spleen function.
HMG levels were significantly higher in diseased or splenectomized patients compared to healthy controls.
A strong correlation was found between HMG expression and spleen dysfunction metrics, such as pit counts.
Higher HMG levels were observed in reticulocytes from sickle cell disease patients compared to healthy individuals.

Cite This Study

Khan et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc75fdc3bde448917b83 https://doi.org/10.1002/ajh.70299

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Implication

This research uncovers the role of high mannose glycans as markers for erythrocyte age in various disease states, indicating spleen function.

High Mannose Glycans: A Marker of Early Red Cell Life and Death

Discussion

Member takes

Implication

Key Points

Cite This Study

High Mannose Glycans: A Marker of Early Red Cell Life and Death

Discussion

Member takes

Implication

Key Points

Cite This Study

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