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April 10, 2026Molecular and Cellular ProbesOpen Access

ZMIZ1 promotes PAX6 ubiquitination through SMAD3 to drive the malignant progression of acute myeloid leukemia

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Authors

LZLili ZhouFirst Affiliated Hospital of Bengbu Medical CollegeJLJiajia LiFirst Affiliated Hospital of Bengbu Medical CollegeMWMeng WangGuizhou University

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Implication

Demonstrates that ZMIZ1 drives tumor growth in acute myeloid leukemia, suggesting new therapeutic approaches.

Key Points

  • This research investigates how ZMIZ1 influences PAX6 ubiquitination through SMAD3 in acute myeloid leukemia.
  • Measured protein levels of ZMIZ1, SMAD3, and PAX6 using Western blot analysis.
  • Conducted in vitro and in vivo experiments to assess cell growth and apoptosis.
  • Performed rescue experiments in HL60 cells to evaluate the role of ZMIZ1 on PAX6 and SMAD3.
  • ZMIZ1 and SMAD3 were found to be elevated in AML patients, while PAX6 levels were decreased.
  • Overexpression of ZMIZ1 enhanced HL60 cell growth and reduced apoptosis.
  • Down-regulation of ZMIZ1 led to decreased tumor growth in animal models.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69d8930e6c1944d70ce04184https://doi.org/10.1016/j.mcp.2026.102070
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