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April 10, 2026International Journal of Molecular SciencesOpen Access

Sex-Specific Effects of Obesity Severity on Circulating Inflammatory Mediators and Immune Cell Gene Expression

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Authors

XCXavier CapóMFM D FerrerASAntoni Sureda

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Overview

Cross-sectional study examines how obesity severity affects inflammatory markers and gene expression, noting gender differences.

Key Points

  • The study investigates how different levels of obesity impact inflammatory markers and immune gene expression, focusing on gender differences.
  • Cross-sectional study design
  • 134 adults aged 55–80 years stratified by obesity severity
  • Plasma cytokines and adipokines measured using multiplex immunoassays
  • Gene expression in immune cells assessed via quantitative PCR
  • Statistical analyses including two-way ANOVA and correlation analyses
  • Obesity severity affects inflammatory profiles differently by gender
  • Women show increased levels of IL-6, while men with severe obesity have higher IL-15 and IL-1rα
  • Hematological responses vary by gender
  • Women express more antioxidant and mitochondrial genes compared to men
  • Weak correlations between circulating inflammatory mediators and immune-cell gene expression

Cite This Study

Capó et al. (2026) studied this question.

synapsesocial.com/papers/69d893896c1944d70ce048b0https://doi.org/10.3390/ijms27073314
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