Si-Ni-San alleviates depression-like behavior via regulating the gut microbiota-tryptophan metabolism-AhR/NF-κB pathway axis

Qiang Xiao; Zhaoyi Wen; Huang Zhan; Han Zhao; Yukun Jiao; Dehua Huang; Hui Li; Chao Chen

doi:10.1186/s13020-026-01390-4

April 7, 2026Chinese MedicineOpen Access

Si-Ni-San alleviates depression-like behavior via regulating the gut microbiota-tryptophan metabolism-AhR/NF-κB pathway axis

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Key Points

The research aims to explore how Si-Ni-San affects depression-like behavior through gut microbiota and metabolic pathways.
Utilized SNS as an intervention to assess its effects on depression-like behavior.
Investigated the role of gut microbiota in tryptophan metabolism.
Analyzed IAA production and its effects on AhR signaling and NF-κB activation.
SNS treatment significantly increased IAA production.
Activated central AhR signaling while suppressing NF-κB-mediated neuroinflammation.
Demonstrated reduced depression-like behavior in the experimental model.

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Implication

Reveals that SNS modulates gut microbiota to enhance IAA production and alleviate depression-like behavior, indicating new therapeutic potential.

Abstract

SNS alleviates depression-like behavior by modulating gut microbiota-mediated tryptophan metabolism to enhance IAA production, thereby activating central AhR signaling and suppressing NF-κB-mediated neuroinflammation.

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Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/69d894326c1944d70ce0522a https://doi.org/10.1186/s13020-026-01390-4

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Si-Ni-San alleviates depression-like behavior via regulating the gut microbiota-tryptophan metabolism-AhR/NF-κB pathway axis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Si-Ni-San alleviates depression-like behavior via regulating the gut microbiota-tryptophan metabolism-AhR/NF-κB pathway axis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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