What question did this study set out to answer?

The study aims to assess the risk of anal squamous cell carcinoma in women with genital high-grade squamous intraepithelial lesions and establish an effective screening strategy.

April 10, 2026International Journal of CancerOpen Access

Risk stratification and anal cancer screening in immunocompetent women with genital HPV : Value of multicentric HSIL and performance of HPV ‐based screening

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Authors

IMIsabel Matasi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto ATAureli TornéHospital Clínic de Barcelona ASAdela Saco

Discussion

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Implication

Cross-sectional study identifies anal HSIL risk in women with genital HPV, suggesting efficient screening methods.

Key Points

The study aims to assess the risk of anal squamous cell carcinoma in women with genital high-grade squamous intraepithelial lesions and establish an effective screening strategy.
Conducted a cross-sectional study with 354 immunocompetent women referred for anal evaluation due to HPV or HSIL.
Categorized participants based on genital site affected by HSIL and included a control group of 99 women.
Performed anal high-risk HPV testing, liquid-based cytology, and high-resolution anoscopy as needed.
62.5% of women showed high-risk HPV infection in the anal canal.
Higher anal HSIL prevalence in women with multicentric disease at 20.7% (p = .031).
Anal high-risk HPV testing alone had 100% sensitivity and negative predictive value for diagnosing HSIL/AIN.

Cite This Study

Matas et al. (2026) studied this question.

synapsesocial.com/papers/69d8946e6c1944d70ce055f5 https://doi.org/10.1002/ijc.70455

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Risk stratification and anal cancer screening in immunocompetent women with genital HPV : Value of multicentric HSIL and performance of HPV ‐based screening

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk stratification and anal cancer screening in immunocompetent women with genital HPV : Value of multicentric HSIL and performance of HPV ‐based screening

Discussion

Member takes

Implication

Key Points

Cite This Study

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