In vivo translation of a dual-stimuli-responsive drug carrier based on mesoporous silica nanoparticles for the co-delivery of camptothecin and 5-fluorouracil

Debatrayee Dasgupta; Sonal Thakore; Anjali Patel; Sriram Seshadri

doi:10.1039/d5pm00390c

January 1, 2026RSC PharmaceuticsOpen Access

In vivo translation of a dual-stimuli-responsive drug carrier based on mesoporous silica nanoparticles for the co-delivery of camptothecin and 5-fluorouracil

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Key Points

The aim is to develop a nanocarrier for the co-delivery of cancer drugs to reduce toxicity and enhance treatment efficacy.
Developed a biotin-targeted mesoporous silica nanocarrier.
Tested the sequential delivery of camptothecin and 5-fluorouracil.
Evaluated the effectiveness in suppressing tumours while monitoring hepatic toxicity.
Demonstrated significant tumour suppression using the dual-drug system.
Observed reduced hepatic toxicity compared to traditional methods.

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Abstract

This work describes a biotin-targeted mesoporous silica nanocarrier that enables sequential and stimuli-responsive co-delivery of camptothecin as well as 5-fluorouracil for enhanced tumour suppression with reduced hepatic toxicity.

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Dasgupta et al. (2026) studied this question.

synapsesocial.com/papers/69d8948f6c1944d70ce05827 https://doi.org/10.1039/d5pm00390c

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In vivo translation of a dual-stimuli-responsive drug carrier based on mesoporous silica nanoparticles for the co-delivery of camptothecin and 5-fluorouracil

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

In vivo translation of a dual-stimuli-responsive drug carrier based on mesoporous silica nanoparticles for the co-delivery of camptothecin and 5-fluorouracil

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

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