Experimental work demonstrates efficient synthesis of functionalized pyridazines from imidazo[1,2-b]pyridazines and amines, suggesting a flexible methodology.
This work describes a practical method for coupling chloropyridazines and aryl/hetero aryl amines to get substituted aryl/hetroarylaminopyridazines. The newly developed condition tolerates a wide range of functional groups, including various heterocycles, electron withdrawing/donating groups, and sensitive functional groups. This approach offers a convenient route to a range of secondary heterocyclic aminopyridazines that were otherwise challenging to synthesize.
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Nimje et al. (2026) studied this question.
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