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April 10, 2026Annals of Internal Medicine Clinical CasesOpen Access

An Unrecognized Case of Glanzmann Thrombasthenia Associated With Gastrointestinal Bleeding

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Authors

FMFangju MaoDepartment of Public HealthCBChristian BraccoAzienda Sanitaria Ospedaliera S.Croce e Carle CuneoTMTeresa MorgilloAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo

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Overview

Case report reveals severe gastrointestinal bleeding in a young man with Glanzmann thrombasthenia, suggesting awareness of this condition is crucial.

Key Points

  • To report an uncommon case of Glanzmann thrombasthenia exhibiting gastrointestinal bleeding symptoms.
  • Clinical assessment of a 22-year-old man
  • Endoscopic evaluation for gastrointestinal issues
  • Platelet aggregation tests with adenosine diphosphate, collagen, and arachidonic acid
  • Flow cytometry for definitive diagnosis
  • Treatment with recombinant activated factor VII and tranexamic acid
  • Patient presented with gastrointestinal bleeding and severe anemia
  • Normal coagulation tests excluded common coagulopathies
  • Platelet aggregation tests confirmed Glanzmann thrombasthenia
  • Successful management with recombinant activated factor VII and tranexamic acid

Cite This Study

Mao et al. (2026) studied this question.

synapsesocial.com/papers/69d895206c1944d70ce06137https://doi.org/10.7326/aimcc.2025.1230
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