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April 7, 2026Journal of Diabetes InvestigationOpen Access

Effects of imeglimin on experimental diabetic neuropathy in streptozotocin‐induced diabetic rats

Wataru Nihei Ayako Kato Takuma Sato Masahiro Yamaguchi Tatsuhito Himeno Nobuhisa Nakamura Kazunori Sango Keiko Naruse Jiro Nakamura Hideki Kamiya Koichi Kato

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Key Points

The aim is to investigate the therapeutic effects of imeglimin on diabetic neuropathy in a rat model.
Induced diabetes in rats using streptozotocin.
Administered imeglimin to assess its effects on diabetic neuropathy.
Conducted behavioral and physiological assessments of neuropathy.
Imeglimin treatment significantly improved symptoms of diabetic neuropathy in rats.
Behavioral tests showed enhanced sensory function after imeglimin administration.

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Implication

Research demonstrates therapeutic effects of imeglimin on diabetic neuropathy in diabetic rats, suggesting clinical relevance.

Abstract

This study provides supporting evidence for the potential therapeutic application of imeglimin in diabetic neuropathy.

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Cite This Study

Nihei et al. (2026) studied this question.

synapsesocial.com/papers/69d895be6c1944d70ce06d53 https://doi.org/10.1111/jdi.70303

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