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April 10, 2026Drug Delivery and Translational ResearchOpen Access

Microfluidic ocular formulation of voriconazole designed for hospital production

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Authors

LSLouise StinatMBMarie BonninJGJean-Christophe Gimel

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Overview

This research designs a nanoemulsion formulation for voriconazole to treat fungal infections, suggesting a new hospital-based preparation.

Key Points

  • The aim was to create a dedicated ocular formulation of voriconazole using a nanoemulsion approach.
  • Developed a 0.4% voriconazole nanoemulsion with oil and surfactants.
  • Utilized phase inversion composition method for nanoemulsion production.
  • Applied microfluidic technology for effective formulation.
  • Adjusted pH and osmolality without destabilizing the nanoemulsion.
  • Conducted in vitro minimal-inhibition-concentration tests on fungal species.
  • Achieved a mean droplet size of approximately 100 nm.
  • Voriconazole was predominantly found in micellar compartments.
  • Found no significant difference in effectiveness compared to the 1% hospital formulation.

Cite This Study

Stinat et al. (2026) studied this question.

synapsesocial.com/papers/69d895d86c1944d70ce06f3bhttps://doi.org/10.1007/s13346-026-02091-z
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