What question did this study set out to answer?

The aim is to understand how Yap1801/2, key factors in endocytosis, are recruited to the plasma membrane in daughter cells during their growth.

April 10, 2026Molecular Biology of the Cell

Polarized anionic phospholipids and exocytosis are implicated in the polarized recruitment of budding yeast AP180, an endocytic initiator

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Authors

PMPaul MarchandoUniversity of California, Berkeley GHGean HuUniversity of California, Berkeley FYFeng YuanUniversity of California, Berkeley

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Implication

Demonstrates the role of anionic phospholipids and exocytosis in recruiting proteins for endocytosis in budding yeast, suggesting important cellular interactions.

Key Points

The aim is to understand how Yap1801/2, key factors in endocytosis, are recruited to the plasma membrane in daughter cells during their growth.
Examined spatiotemporal dynamics of fluorescently tagged Snc2 in yeast.
Used functional assays to analyze interactions with Yap1802.
Explored the role of anionic phospholipids in protein recruitment.
Snc2 recruits Yap1802 to growing daughter cells.
This recruitment is linked to anionic phospholipids.
The findings suggest a connection between polarized secretion and endocytosis initiation.

Cite This Study

Marchando et al. (2026) studied this question.

synapsesocial.com/papers/69d895d86c1944d70ce0700b https://doi.org/10.1091/mbc.e24-10-0446

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Implication

Demonstrates the role of anionic phospholipids and exocytosis in recruiting proteins for endocytosis in budding yeast, suggesting important cellular interactions.

Polarized anionic phospholipids and exocytosis are implicated in the polarized recruitment of budding yeast AP180, an endocytic initiator

Discussion

Member takes

Implication

Key Points

Cite This Study

Polarized anionic phospholipids and exocytosis are implicated in the polarized recruitment of budding yeast AP180, an endocytic initiator

Discussion

Member takes

Implication

Key Points

Cite This Study

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