Key result
In yeast, polarized growth and organelle segregation require formin-dependent assembly of actin cables, which are used by myosin V motors to deliver secretory vesicles, organelles, and mRNA.
This review synthesizes the molecular mechanisms by which yeast cells use actin cables and myosin V motors to achieve polarized growth and organelle segregation.
May guide polarized cell studies; leaves open relevance to mammalian cardiovascular models.
In yeast, growth and organelle segregation requires formin-dependent assembly of polarized actin cables. These tracks are used by myosin Vs to deliver secretory vesicles for cell growth, organelles for their segregation, and mRNA for fate determination. Several specific receptors have been identified that interact with the cargo-binding tails of the myosin Vs. A recent study implicates specific degradation in the bud of the vacuolar receptor, Vac17, as a mechanism for cell cycle-regulated segregation of this organelle.
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Anthony Bretscher (2003) conducted a review in Cell polarity and organelle segregation in yeast. In yeast, polarized growth and organelle segregation require formin-dependent assembly of actin cables, which are used by myosin V motors to deliver secretory vesicles, organelles, and mRNA.
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