Population
Saccharomyces cerevisiae (yeast) cells
Comparison
Random mutagenesis of the globular tail of Myo2p… vs Wild-type or other mutants (e.g., myo2-2)
Design
Preclinical
Authors
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Distinct myosin-V subdomains mapped in yeast; leaves open conservation and roles in mammalian cargo transport.
The identification of distinct subdomains in the cargo-binding domain of yeast myosin-V suggests how it can move multiple cargoes and that the vacuole receptor differs from the essential cargo receptor.
Catlett et al. (2000) studied this question.
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