Key result
Simultaneous expression of the separate Myo2p globular tail subdomains I and II produces a functional complex in vivo, demonstrating that their tight association is required for cargo attachment.
Intramolecular interactions between the globular tail subdomains of myosin V help coordinate the transport of multiple distinct cargoes.
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Should not alter clinical practice; leaves open myosin V subdomain roles in mammalian cardiovascular transport.
Pashkova et al. (2005) studied this question. Coexpression of Myo2p globular tail subdomains I and II vs. Expression of individual subdomains was evaluated on Vacuole inheritance and protein interaction. Simultaneous expression of the separate Myo2p globular tail subdomains I and II produces a functional complex in vivo, demonstrating that their tight association is required for cargo attachment.
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