Key result
A point mutation in subdomain I of yeast myosin V, myo2-2(G1248D), causes a conformational change that simultaneously affects its interaction with multiple cargoes.
A specific point mutation in the yeast myosin V cargo-binding domain induces a conformational change that impairs its interaction with multiple cargoes, highlighting the structural interdependence of its subdomains.
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Does not inform clinical decisions; leaves open whether subdomain interdependence extends to mammalian myosin V in disease.
Pashkova et al. (2005) studied this question. myo2-2(G1248D) point mutation was evaluated on Interaction with multiple cargoes and vacuole inheritance. A point mutation in subdomain I of yeast myosin V, myo2-2(G1248D), causes a conformational change that simultaneously affects its interaction with multiple cargoes.
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